Today shall be dedicated to the study of feedback mechanisms, via hormones and nerves, during load/ exercise.
First on my checklist, "various stress hormones need to spike, to their respective activation thresholds, in order to activate certain negative feedback loops". So, loading below certain stress thresholds does not meet this criteria for development.
Second, by the time severe negative feedback is triggered, it is almost certain that many lesser thresholds for positive feedback have already been triggered. These two series of triggers may have an overlapping range, so chronologically it is expected that there will be intermittent triggers of both positive and negative feedback, until the ratio between these starts to skew too strongly towards the negative. This bears observation intra-session of loading.
Third, both positive and negative feedback mechanisms will interact with nutrient availability across the entire timeframe from days before to days after each loading session. As the windows for some of these interactions are so long, loading more than once a week results in a series of overlapping frames. So inter-session observation is also needed.