Hypothesis: caffeine mimics adrenaline, i.e. it increases metabolic rate. So, in order to maintain CO2 and O2 levels in the blood, a caffeine user literally has to increase volume or rate of breath under standard atmospheric conditions. Failure to increase airflow results in the activation of the usual reflexes reacting to respiratory acidosis or hypoxia. That is how caffeine stresses people out. This is kinda enlightening.
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